PERBEDAAN PENGARUH MUSIK BEETHOVEN DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP INDEKS APOPTOSIS NEURON
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Published:
May 21, 2020
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Keywords: Beethoven, Chopin, Indeks Apoptosis
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Abstract
The efforts that can be done to improve brain cells in the prenatal period is the provision of nutrients and good stimulation. Exposure to classical music such as Beethoven can increase the wave of brain activity. During pregnancy, Beethoven music is proven to decrease the apoptosis of neuronal. Laboratory experimental research, posttest-only control group design. Subjects were female pregnant Rattus norvegicus, grouped into 3 random groups: 1 control group and 3 treatments groups; with 6 samples each. Subjects were super ovulated, and 65 dB intensity of music was played for an hour at 8-9 pm on the subjects on 10th day of pregnancy. On 20th day of pregnancy, the mothers were dissected using sectio caesarea. 2 heaviest offspring’ of Rattus norvegicus taken, and their brain tissues are taken as samples. The mean of apoptosis neuronal of rat offspring’ cerebrum were respectively from the low to high levels as follow Beethoven 1,57±0,3 and Chopin 1,77±0,81, control 1,97±0,34. The data were analysed using Kruskal-Wallis test which showed significant differences between four groups p=0,014 in cerebrum.
In conclusion, exposure of Beethoven composition during pregnancy gave lower apoptosis of neuronal cerebrum in the offspring-rat compared with Chopin composition.
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Fajrin, D. H. (2020). PERBEDAAN PENGARUH MUSIK BEETHOVEN DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP INDEKS APOPTOSIS NEURON. JURNAL KESEHATAN MERCUSUAR, 3(1), Page 66–72. https://doi.org/10.36984/jkm.v3i1.67
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References
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Yeh, E. T. H. 1998. Life and Death of the Cell. Hospital Practice. 33(8): 85-92.
Yuan, J., and Yanker, B. A. 2000. Apoptosis in The Nervouse System. Nature. (32):802-809.
Alonso, M., Mediana, J. H., & Pozzo, L. 2004. ERK1/2 Activation Is Necessaray for BDNF to Increase Dendritic Spine Density in Hippocampal CA1 Pyramidal Neurons. Learning Memory. 172-178
Cameron, J.R., Skofronick J.G., and Grant R. M. 2006. Fisika Tubuh Manusia. Sagung Seto, Jakarta. P: 280-301
Campbell, D. 2002. Efek Mozart Memanfaatkan Kekuatan Musik Untuk Mempertajam Pikiran, Meningkatkan Kreativitas dan Menyehatkan Tubuh. Gramedia Utama. Jakarta.
Campbell, D. 2003. The Mozart Effect for Parents: Unlocking the potential of your child. Penguin publishers, New York.
Chelderon, F., and Kim, H. Y. 2004. Docosahexaenoic acid promotes neurit growth in hipocampal neurons. Journal of Neurochemistery Lippincott Williams and Wilkins. 90: 979-98.
Carter, A. R., Chen C., Schwarts P.M., and Segal, R. A. 2002. Brain-Derived Neurotropic Factor Modulates Cerebellar Plasticity and Synaptic Ultrastructure. The Journal of Neuros cience, February. 22(4):1316-1327
Colombo, J.A., Reisin, H.D., Hidalgo, J.J.M., and Rajkowska, G. 2006. Barin Res Brainresrev. 52(2): 257-263.
Chabris L. 1999. The Mind of Your Newborn Baby. Nort Atlantic Books Berkeley: California.
Nagpal, J., Arora, K., and Nagpalm B. 2015. Environment and Intelligence: A Corellation. International Journal of Engineering Technology Science and Research. 2(11): 107-114.
Nicholson, K. M and Anderson, N. G. 2002. The Protein Kinase B/Akt Signaling pathway in Human Malignancy. Cellular Signalling. 14(5): 381-395.
Pistilli, E., Siu, P. M., and Always, S. E. 2006. Molecular Regulation of Apoptosis in Fast Plantaris Muscles of Aged Rats. J Gerontol A. Biol Sci Med Sci. 61(3): 245-255.
Pizem, J., and Cor, A. 2003. Detection of Apoptotic Cell in Tumor Paraffin Section. Radiology Oncology. 37(4): 225-232.
Pujol, R. 2016. Auditory Brain Journey Into The World of Hearing. [Accessed 12 November 2017].
Rahayu. 2004. Pertumbuhan dan Perkembangan Embrio Tikus Putih (Rattus novergicus) Setelah Perlakuan Kebisingan. BioSMART. 7(1): 53-59.
Rauscher, F. H., Robinson, K.D., and Jens, J. 1998. Improved Maze Learning Trough Early Music Exprosure In Rats. Neurological Research. 20(5): 427-432.
Rebillard, G., and Pujol, R. 2016. Cochlea: Function. Journey Into The World of Hearing.
Reed, J.C. 2000. Mechanism of Apoptotic. American Journal of Pathology. 157(5): 1415-1430.
Rees, S., and Walker, D. 2001. Nervous and Neuromuscular System. Feral Growth and development. 1: 154-185.
Rizarina, S., Hermanto, T. J., Estopangesti, A. T. S., and Widjiati. 2005. Perbandingan Indeks Apoptosis Otak Anak Tikus Baru Lahir yang Mendapat Paparan dan Tidak Mendapat Paparan lagu Mozart Sejak Kebuntingan. Departemen Obstetri dan Ginekologi FK Unair/RS dr Soetomo. Surabaya.
Rodeck, C. H. And Whittle, M, J. 1999. Fetal Medicine. Basic Science and Clinical Practice. London, UK: Churchill Livingstone.
Roy, S., Sablr, P. Khaire, A., Randhir, K., Khale, A., and Joshi, S. 2013. Effect of Maternal Micrount Rients (folicacid and vitamin B12) and Omega 3 Fatty Acid Onindices of Brain Oxidative
Sari, N. R. 2005. Musik dan Kecerdasan Otak Bayi. Bogor: Kharisma Buta Aksara
Sanyal, T., Kumar, V., Nag, T.C., Jain, S., Sreenvas, V., and Wadhwa, S. 2013. Prenatal Loud Music and Noise : Differential Impact on Physiological Arousal, Hippocampal Synaptogenesis and Spatial Behavior in One Day-old Chicks. 8(7).
Siegal, A., and Sapru, H, N. 2010. Essential Neuroscience. Philadelphia: Lippincott Williams & Wilkins.
Song, G., Ouyang, G., dan Bao, S. 2005. The Activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med. 9(1): 59-71.
Story, L. 2003. A Head Start in Life? Prenatal Parenting and Discourse of Fetal Stimulation. Atlantis. 41-48.
Thomas, K., and Davies, A. 2005. Neurotrophins: a Ticket to Ride for BDNF. Current Biology 15(7): 03-23.
United Nations Development Programme [UNDP]. 2015. Human Development Report 2015. New York.
Verny, T., and Kelly, J. 1982. The Secret Life of The Unborn Child. Dell
Verrusio, W., Ettore, E., Vicenzini, E., Vanacore, N., Cacciafesta, M., and Mecarelli, O. 2015. The Mozart Effect: A Quantitative EEG Study. Consciousness and Cognition. (35):150-155.
Volpe, and Joseph, J. 2008. Neurology of The Newborn (4th ed.). Philadelphia. USA : W.B. Saunders.
Whitwell, G. E. 2006. The Importance of Prenatal Sound and Music. Journal of Prenatal & Perinatal Psychology & Health. 13(4): 1-13.
Widodo, D. P. 2000. Pertumbuhan dan Perkembangan Susunan Saraf Pusat pada Janin dan Bayi. Paper Presented at The Konas Perinasia Vii. Semarang.
Xing, Y., Xia, Y., Kendrick, K., Liu, X., Wang, M., Wu, D., Yang, H., Jing, W., Guo, D & Yao, D. 2015. Mozart, Rhythm and Retrograde Mozart Effect: Evidences from Behaviours and Neurobiology Bases. Nature: Scientific Reports. 1-11.
Yeh, E. T. H. 1998. Life and Death of the Cell. Hospital Practice. 33(8): 85-92.
Yuan, J., and Yanker, B. A. 2000. Apoptosis in The Nervouse System. Nature. (32):802-809.